Empacip S 25/100

EMPACIP S 25/100 Tablet

EMPACIP S 25/100 Tablet, manufactured by Cipla Ltd., is a combination medication used in the management of Type 2 Diabetes Mellitus. It works as an adjunct to diet and exercise to help improve blood sugar control in adults. This medication also aids in reducing the risk of cardiovascular events and may slow the progression of kidney disease associated with diabetes.

Composition Each tablet contains:

• Empagliflozin: 25 mg (a sodium-glucose co-transporter 2 (SGLT2) inhibitor)
• Sitagliptin: 100 mg (a dipeptidyl peptidase-4 (DPP-4) inhibitor)

Empagliflozin works by blocking SGLT2 in the kidneys, which leads to increased removal of glucose through urine, thereby lowering blood sugar levels. Sitagliptin works by increasing incretin levels in the body, enhancing insulin release after meals, and reducing glucose production by the liver.

Uses EMPACIP S 25/100 Tablet is primarily used for:

• Improving glycemic control in adults with Type 2 Diabetes Mellitus.
• Reducing the risk of cardiovascular death in adults with Type 2 Diabetes Mellitus and established cardiovascular disease.
• Potentially slowing the progression of kidney disease (diabetic nephropathy).

Dosage and Administration The recommended daily dose of EMPACIP S 25/100 Tablet should be taken as advised by your doctor. It is typically taken orally once daily, preferably in the morning. The tablet can be taken with or without food and should be swallowed whole with water; do not chew, crush, or split the tablet. It is important to take the medicine at the same time each day to maintain consistent blood levels. If a dose is missed, take it as soon as remembered unless it is almost time for the next scheduled dose, in which case the missed dose should be skipped to avoid a double dose.

Side Effects Common side effects may include:

• Urinary tract infections (UTIs)
• Vaginal yeast infections or other genital infections
• Increased urination or thirst
• Rash or itching
• Constipation
• Headache
• Nausea, vomiting, diarrhea, abdominal pain
• Hypoglycemia (low blood sugar), especially when used with insulin or sulfonylureas

Serious but less common side effects can include ketoacidosis, severe dehydration, or kidney problems. Allergic reactions are also possible. Consult your doctor if any side effects persist or worsen.

Precautions

• Pregnancy and Breastfeeding: EMPACIP S 25/100 is not recommended during pregnancy or breastfeeding due to potential harm to the baby.
• Alcohol: Avoid excessive alcohol consumption as it can cause fluctuations in blood sugar levels, increase the risk of dehydration, and raise the risk of lactic acidosis.
• Kidney/Liver Impairment: Use with caution in patients with liver impairment. It is not recommended for individuals with severe kidney impairment or those on dialysis.
• Type 1 Diabetes/Ketoacidosis: This medicine is not suitable for individuals with Type 1 Diabetes or diabetic ketoacidosis.
• Dehydration: There is a risk of dehydration, especially with vomiting, diarrhea, fever, or if taking diuretics. Increase fluid intake.
• Drug Interactions: Inform your doctor about all medications, supplements, and herbal products you are taking, especially diuretics, insulin, sulfonylureas, rifampin, corticosteroids, sympathomimetics, and lithium, as interactions can occur.
• Pancreatitis: Patients with a history of pancreatitis should use this medicine with caution.
• Driving: The medication may cause dizziness or sleepiness, so exercise caution while driving or operating machinery.
• Older Patients: Use with caution in older adults.

Storage Store EMPACIP S 25/100 Tablet below 30°C in a cool, dry place. Keep this medicine out of the sight and reach of children and pets. Do not use the medicine after the expiry date.

EMPACIP S 25/100 by CIPLA LTD is a combination medication containing Empagliflozin (25 mg) and Sitagliptin (100 mg). It is primarily used to treat type 2 diabetes mellitus in adults, alongside diet and exercise.

What is EMPACIP S 25/100 used for?

EMPACIP S 25/100 is used to control high blood sugar levels in adults with type 2 diabetes mellitus. It also helps in reducing the risk of cardiovascular death and slowing the progression of kidney disease (diabetic nephropathy) in eligible patients.

How does EMPACIP S 25/100 work?

This medicine combines two active ingredients: Empagliflozin and Sitagliptin. Empagliflozin, an SGLT2 inhibitor, works by preventing the kidneys from reabsorbing glucose, leading to excess sugar being excreted in the urine, thus lowering blood sugar levels. Sitagliptin, a DPP-4 inhibitor, increases the levels of incretin hormones, which stimulate insulin release from the pancreas and reduce glucagon secretion from the liver, further helping to regulate blood sugar.

What is the usual dosage?

EMPACIP S 25/100 is typically taken once daily, preferably in the morning, with or without food. It is crucial to follow your doctor's instructions regarding dosage and timing and to maintain a consistent schedule by taking the tablet at the same time each day. The tablet should be swallowed whole with a full glass of water and not crushed, chewed, or broken.

What are the possible side effects?

Common side effects may include urinary tract infections (UTIs), yeast infections (genital fungal infections), increased urination, thirst, dehydration, headache, nausea, vomiting, diarrhea, abdominal pain, and rash. Less common but serious side effects can include ketoacidosis (high levels of ketones in blood or urine) and Fournier's gangrene (a rare but serious genital infection). It's important to stay hydrated and report any persistent or bothersome side effects to your doctor.

Is it safe during pregnancy or breastfeeding?

EMPACIP S 25/100 is generally not recommended during pregnancy as it may cause harm to the unborn baby. For breastfeeding mothers, it is not known if the components pass into human breast milk, but animal studies suggest they might. Therefore, it is generally advised not to use this medicine while breastfeeding unless specifically recommended by a doctor. Always consult your doctor for safer alternatives if you are pregnant, planning to become pregnant, or breastfeeding.

Can it be taken with other medications?

Yes, but caution is advised as EMPACIP S 25/100 can interact with several medications. Inform your doctor about all prescription drugs, over-the-counter medications, and herbal supplements you are taking. Particular attention should be paid if you are taking diuretics, insulin, sulfonylureas, lithium, antibiotics (like rifampin), corticosteroids, or sympathomimetics, as these can affect how EMPACIP S works or increase the risk of side effects like low blood sugar or dehydration.

What precautions should be taken?

Do not use EMPACIP S 25/100 if you have type 1 diabetes or diabetic ketoacidosis. Inform your doctor about any history of kidney or liver problems, heart conditions, or urinary tract infections. Be aware of the risk of dehydration, especially if you are vomiting, have diarrhea, fever, or are taking diuretics; ensure adequate fluid intake. Avoid excessive alcohol consumption as it can increase the risk of low blood sugar and lactic acidosis. Regular monitoring of blood sugar levels and kidney function is essential.

What happens if a dose is missed?

If you miss a dose of EMPACIP S 25/100, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.

How should it be stored?

EMPACIP S 25/100 should be stored in a cool, dry place, away from direct sunlight and moisture, and out of reach of children and pets. Do not store it in the bathroom.