Olkem Trio 12.5 Mg Tablet (10 Tab)

OLKEM TRIO 12.5 MG TABLET

OLKEM TRIO 12.5 MG TABLET is a medication manufactured by Alkem Laboratories Ltd., primarily prescribed for the management of high blood pressure (hypertension). This combination medicine helps to relax blood vessels, remove excess water from the body, and improve blood flow, thereby lowering blood pressure effectively and reducing the risk of heart attack and stroke.

• Name: Olkem Trio 12.5 Tablet (Brand Name)
• Composition:
  • Olmesartan medoxomil (20 mg)
  • Cilnidipine (10 mg)
  • Chlorthalidone (12.5 mg)
• Uses:
  • Treatment of essential hypertension (high blood pressure) in adults.
  • Lowering the risk of strokes and heart attacks by controlling hypertension.
  • Providing comprehensive blood pressure control, potentially reducing the need for multiple medications.
• Dosage and Administration:
  • Take as advised by your physician, typically once daily.
  • Swallow the tablet whole with a glass of water; do not crush or chew.
  • It can be taken with or without food, though taking it with food may help mitigate nausea.
  • Avoid taking this medicine within four hours of going to bed due to its diuretic effect, which can increase urine output.
  • Do not stop taking the medicine without consulting your doctor, as this may lead to a rise in blood pressure.
• Side Effects:
  • Common: Dizziness, headache, nausea, fatigue, peripheral oedema (swelling of legs/hands), muscle spasms, sore throat, runny nose, stomach pain, indigestion, diarrhea, constipation, chills, and skin rash.
  • Serious (seek immediate medical attention): Severe light-headedness or fainting due to low blood pressure, signs of liver damage (jaundice), signs of kidney failure, or abnormal heart rhythm.
• Precautions:
  • Contraindications: Not recommended during pregnancy or breastfeeding. Avoid if allergic to any components or other sulfonamide antibiotics, or if you have low blood pressure, cardiogenic shock, aortic stenosis, anuria, severe liver or kidney failure, or are taking Aliskiren with diabetes.
  • Warnings: Use with caution in patients with liver or kidney disease, heart failure, or existing low blood pressure. Regular monitoring of electrolytes is necessary due to potential imbalances.
  • Avoid or limit alcohol consumption, as it may increase dizziness and risk of low blood pressure.
  • Do not drive or operate machinery if experiencing dizziness or drowsiness.
  • Avoid consuming grapefruit juice and St. John's wort while on this medication.
• Storage:
  • Store at room temperature (20-25°C) and protect from moisture and light.
  • Keep out of the reach of children and pets.

OLKEM TRIO 12.5 MG TABLET: Frequently Asked Questions

What is OLKEM TRIO 12.5 MG TABLET used for?

OLKEM TRIO 12.5 MG TABLET is primarily used to manage essential hypertension, also known as high blood pressure, in adults. It helps lower blood pressure and reduce the risk of associated complications such as heart attacks and strokes.

How does OLKEM TRIO 12.5 MG TABLET work?

OLKEM TRIO 12.5 MG TABLET is a combination of three active ingredients: Olmesartan medoxomil, Cilnidipine, and Chlorthalidone.

• Olmesartan medoxomil is an angiotensin receptor blocker (ARB) that works by blocking a natural enzyme (Angiotensin II) that causes blood vessels to tighten. This helps relax blood vessels, allowing blood to flow more easily.
• Cilnidipine is a calcium channel blocker (CCB) that prevents calcium from entering vascular smooth muscle cells. This relaxes blood vessels, reduces the heart's workload, and improves pumping efficiency.
• Chlorthalidone is a diuretic (water pill) that helps the body eliminate excess water and certain electrolytes, such as sodium and chloride, through urine. This reduces fluid volume and helps lower blood pressure.

What is the usual dosage for OLKEM TRIO 12.5 MG TABLET?

The dosage of OLKEM TRIO 12.5 MG TABLET is determined by your doctor based on your medical condition and response to the medication. It is usually taken once a day, with or without food, preferably in the daytime and at a fixed time to achieve optimal benefits. You should swallow the tablet whole with a glass of water without crushing or chewing it.

What are the possible side effects of OLKEM TRIO 12.5 MG TABLET?

Common side effects can include dizziness, headache, nausea, indigestion, diarrhea, stomach pain, and swelling of the ankles or hands (peripheral edema). Other possible side effects may include tiredness, sore throat, runny or stuffy nose, cough, shortness of breath, fever, chills, and muscle pain.

More serious but less common side effects that require immediate medical attention include severe light-headedness or fainting due to very low blood pressure, muscle cramps or irregular heartbeat (which can be due to low potassium), yellowing of the skin and eyes (jaundice, a sign of liver trouble), sudden weight gain or swelling (signs of kidney issues), skin rash, itching, or trouble breathing (possible allergic reaction).

Is OLKEM TRIO 12.5 MG TABLET safe during pregnancy or breastfeeding?

OLKEM TRIO 12.5 MG TABLET is generally not recommended for use during pregnancy or if you are planning to become pregnant, as it may harm the unborn baby. If you become pregnant while taking this medicine, discontinue treatment and consult your doctor immediately.

For breastfeeding, components of this medicine can pass into breast milk. The effect on infants is not well known, so it is generally not recommended. You should inform your doctor if you are breastfeeding before initiating treatment.

Can OLKEM TRIO 12.5 MG TABLET be taken with other medications?

It is crucial to inform your doctor about all other medicines, herbal preparations, and supplements you are currently taking or might take to avoid potential interactions.

Some medications that may interact with OLKEM TRIO 12.5 MG TABLET include:

• Potassium supplements and potassium-sparing diuretics (e.g., amiloride, spironolactone)
• Other blood pressure medicines, especially aliskiren (contraindicated in patients with diabetes or kidney disorders)
• Blood-thinning medications like heparin.
• Medicines used to relieve pain, swelling, and inflammation (NSAIDs) like ibuprofen, aceclofenac.
• Lithium (used for brain-related disorders).
• Certain antacids.
• Medicines for lowering cholesterol, and anti-epileptic medicines.
• Digoxin (for heart failure).
• Cimetidine (for stomach ulcers), rifampicin (for tuberculosis), itraconazole, miconazole (for fungal infections).

Avoid consuming grapefruit juice while taking this medicine, as it may increase the levels of the medicine in the body.

What precautions should be taken?

• Allergies: Do not take OLKEM TRIO 12.5 MG TABLET if you are allergic to any of its ingredients or other sulfonamide antibiotics.
• Underlying Medical Conditions: Exercise caution and inform your doctor if you have very low blood pressure, heart disorders (e.g., heart failure, cardiogenic shock, aortic stenosis), liver or kidney problems (especially severe impairment or anuria), diabetes, gout, high blood potassium levels, or problems with your adrenal glands.
• Dehydration: This medicine contains a diuretic and may cause dehydration. Drink plenty of fluids and inform your doctor if you experience extreme thirst, muscle weakness, or a very dry mouth.
• Driving and Alcohol: OLKEM TRIO 12.5 MG TABLET may cause dizziness or tiredness, so be cautious when driving or operating machinery. Avoid consuming alcohol as it can aggravate side effects like dizziness and low blood pressure.
• Diet: Maintain a low-salt diet to help manage blood pressure effectively.

What happens if a dose is missed?

If you miss a dose of OLKEM TRIO 12.5 MG TABLET, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to compensate for the missed one.

How should it be stored?

OLKEM TRIO 12.5 MG TABLET should be stored at room temperature (20-25°C), away from heat, direct light, and moisture. Keep it out of the reach of children and pets.