Nebistar H Tablet (15 Tab)

NEBISTAR H TABLET

NEBISTAR H TABLET is a prescription medication manufactured by Lupin Ltd., used for the effective management of high blood pressure (hypertension).

Composition

NEBISTAR H TABLET contains two active ingredients:

• Nebivolol (5 mg): A highly selective beta-1 adrenergic receptor blocker that works by relaxing blood vessels, slowing down the heart rate, and reducing the force with which the heart pumps blood.
• Hydrochlorothiazide (12.5 mg): A thiazide diuretic ("water pill") that helps the kidneys eliminate excess salt and water from the body, thereby reducing blood volume and lowering blood pressure. It also has a mild vasodilatory effect.

Uses

NEBISTAR H TABLET is primarily used for:

• Management of high blood pressure (hypertension) in adults.
• Effective control of hypertension when either nebivolol or hydrochlorothiazide alone is insufficient.
• Reducing the risk of heart-related complications such as heart attack, stroke, and kidney problems associated with prolonged high blood pressure.

Dosage and Administration

The typical dosage is one tablet daily, but it is crucial to follow your physician's prescription as it may vary based on individual health conditions.

• Take the tablet orally with a glass of water, with or without food.
• It is recommended to take the medicine at the same time each day, preferably in the morning, to maintain consistent levels in the body and avoid frequent urination at night.
• Swallow the tablet whole; do not chew, crush, or break it.
• Do not stop taking this medicine abruptly without consulting your doctor, as it can lead to a sudden rise in blood pressure, increasing the risk of heart attack and stroke.

Side Effects

While using NEBISTAR H TABLET, some individuals may experience side effects. Most common side effects are temporary and usually resolve on discontinuation of the medicine.

• Common Side Effects: Headache, dizziness, fatigue, nausea, diarrhea, constipation, insomnia (difficulty sleeping), bradycardia (slower-than-normal heart rate), impotence, decreased libido, increased urination, dry mouth, increased blood uric acid, decreased potassium and magnesium levels in blood, glucose intolerance, altered blood lipid levels, breathlessness, swelling of hands and feet, and paresthesia (tingling or pricking sensation).
• Serious Side Effects: In rare cases, severe allergic reactions, including swelling of the face, lips, tongue, or throat (angioedema), and severe skin reactions like Stevens-Johnson syndrome, may occur. Seek emergency medical help if you experience such symptoms.

Precautions

Before taking NEBISTAR H TABLET, inform your doctor about any existing medical conditions or ongoing medications.

• Medical Conditions: Use with caution in patients with liver disease, kidney disease (especially severe impairment), diabetes, asthma or other respiratory conditions, thyroid disorders, poor blood circulation, or a history of psoriasis. It is not recommended for patients with severe heart problems such as heart failure, heart block (greater than first degree), or severe bradycardia.
• Pregnancy and Breastfeeding: Consult your doctor if you are pregnant, planning a pregnancy, or breastfeeding.
• Alcohol Consumption: Limit alcohol consumption as it may enhance side effects like dizziness or drowsiness and further lower blood pressure.
• Driving and Operating Machinery: This medicine may cause dizziness or affect vision; avoid activities requiring high mental alertness, such as driving or operating heavy machinery, if you experience these symptoms.
• Monitoring: Regular monitoring of blood pressure, kidney function, blood sugar levels, and electrolyte levels (like potassium and magnesium) may be required.

Storage

Store NEBISTAR H TABLET below 30°C. Keep it in the original container to protect it from light and moisture.

Here are the most frequently asked questions about NEBISTAR H TABLET (15 TAB) by LUPIN LTD. along with concise answers:

What is NEBISTAR H TABLET used for?

NEBISTAR H TABLET is primarily used to manage high blood pressure (hypertension) in adults. It is often prescribed when a single medication is not sufficient to control blood pressure effectively. By lowering blood pressure, it helps reduce the risk of serious heart-related complications such as heart attack, stroke, and kidney problems.

How does NEBISTAR H TABLET work?

NEBISTAR H TABLET contains two active ingredients: Nebivolol (5 mg) and Hydrochlorothiazide (12.5 mg). Nebivolol is a beta-blocker that works by relaxing blood vessels, slowing down the heart rate, and reducing the force with which the heart pumps blood. Hydrochlorothiazide is a diuretic (water pill) that helps the kidneys eliminate excess salt and water from the body, thereby reducing blood volume and lowering blood pressure. The combination of these two agents provides a synergistic effect, leading to more effective blood pressure control.

What is the usual dosage for NEBISTAR H TABLET?

The usual dosage for NEBISTAR H TABLET is typically one tablet daily, but it is crucial to follow your doctor's specific prescription. The dosage may vary based on your health condition and how you respond to the medicine. It can be taken with or without food, preferably in the morning to avoid frequent urination at night. Swallow the tablet whole with water; do not crush, chew, or break it, and take it at the same time each day for optimal effectiveness.

What are the possible side effects of NEBISTAR H TABLET?

Common side effects may include headache, dizziness, fatigue, nausea, diarrhea, constipation, insomnia (difficulty sleeping), slower-than-normal heart rate (bradycardia), decreased libido, and impotence. Other possible side effects include tingling or pricking sensations, swelling of hands and feet, abdominal pain, increased blood uric acid, and changes in electrolyte levels (decreased potassium or magnesium, increased calcium). Most side effects are usually temporary and resolve as your body adjusts to the medication. If any side effects persist, worsen, or concern you, consult your doctor.

Is NEBISTAR H TABLET safe during pregnancy or breastfeeding?

NEBISTAR H TABLET is generally not recommended during pregnancy as it may have undesirable effects on the developing fetus. Animal studies have shown harmful effects, and human data is limited. Similarly, it is probably unsafe to use during breastfeeding as limited human data suggests the drug may pass into breastmilk and harm the baby. Always consult your doctor for advice if you are pregnant, planning a pregnancy, or breastfeeding.

Can NEBISTAR H TABLET be taken with other medications?

NEBISTAR H TABLET can interact with several other medications. Non-steroidal anti-inflammatory drugs (NSAIDs) like ibuprofen can reduce its blood pressure-lowering effects. It may also interact with cardiac glycosides (e.g., digoxin), antidiabetic medicines, certain heart-related medicines, laxatives, other diuretics, corticosteroids, and some antidepressants. It is essential to inform your doctor about all prescription and over-the-counter medicines, supplements, and herbal products you are currently taking to avoid potential drug interactions.

What precautions should be taken while using NEBISTAR H TABLET?

Do not stop taking NEBISTAR H TABLET suddenly without consulting your doctor, as this can lead to a sudden and dangerous rise in blood pressure. Inform your doctor about any pre-existing health conditions such as liver or kidney problems, heart disorders (like slow heartbeat, heart block, or heart failure), asthma, diabetes, thyroid problems, or electrolyte imbalances. Alcohol consumption should be limited or avoided as it can increase side effects like dizziness or drowsiness. This medicine may cause dizziness or tiredness, so be cautious while driving or operating machinery. Regular monitoring of your blood pressure, kidney function, blood sugar, and electrolyte levels may be advised by your doctor.

What happens if a dose of NEBISTAR H TABLET is missed?

If you miss a dose of NEBISTAR H TABLET, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one.

How should NEBISTAR H TABLET be stored?

NEBISTAR H TABLET should be stored at room temperature, ideally below 30°C. Keep the medicine in its original container, in a dry place, and protected from light and moisture.