Nucoxia 120 Tablet

NUCOXIA 120 TABLET by ZYDUS CADILA

Nucoxia 120 Tablet is a prescription pain-relieving medicine manufactured by Zydus Cadila, primarily used for its anti-inflammatory properties.

• Name

  • Brand Name: Nucoxia 120 Tablet
  • Common Name (Active Ingredient): Etoricoxib

• Composition

  • Each tablet contains Etoricoxib 120 mg. Etoricoxib is a selective COX-2 inhibitor, a type of non-steroidal anti-inflammatory drug (NSAID), which works by blocking the enzyme COX-2 to reduce the production of prostaglandins responsible for pain, swelling, and inflammation.

• Uses Nucoxia 120 Tablet is used to alleviate pain, swelling, and inflammation associated with various conditions:

  • Osteoarthritis
  • Rheumatoid Arthritis
  • Ankylosing Spondylitis
  • Acute Gouty Arthritis
  • Moderate pain after dental surgery
  • Acute musculoskeletal injuries
  • Chronic low back pain
  • Dysmenorrhea (painful menstruation)

• Dosage and Administration Nucoxia 120 Tablet should be taken in the dose and duration advised by your doctor.

  • The tablet should be swallowed whole with a glass of water.
  • It can be taken with or without food, though taking it with food or milk may help reduce stomach discomfort.
  • Do not crush, break, or chew the tablet.
  • For acute gouty arthritis, the typical dosage is 120 mg once daily for the shortest duration necessary, usually not exceeding 8 days.
  • It is generally taken once daily.
  • Do not exceed the prescribed dose.

• Side Effects Common side effects may include:

  • Abdominal pain
  • Diarrhea
  • Indigestion or discomfort in your stomach (dyspepsia, heartburn)
  • Nausea and vomiting
  • Dizziness and headache
  • Rash and itching
  • Feeling of tiredness or lack of energy (fatigue, general weakness)
  • Increased blood pressure (hypertension)
  • Swelling of the legs and feet (edema)
  • Palpitations (pounding heart)
  • Shortness of breath
  • Constipation and flatulence
  • Gastritis (inflammation of the lining of the stomach)
  • Mouth ulcers
  • Dry socket (after dental surgery)
  • Flu-like illness (fever, cold, cough, or sore throat)

  Serious side effects or persistent symptoms should be reported to a doctor.

• Precautions

  • Allergies: Do not take Nucoxia 120 Tablet if you are allergic to etoricoxib, other painkillers (NSAIDs) like aspirin or ibuprofen, or any other ingredients in the tablet.
  • Pregnancy and Breastfeeding: Nucoxia 120 Tablet is contraindicated during pregnancy and for breastfeeding women.
  • Heart Conditions: Use with caution if you have a history of heart problems, heart failure, high blood pressure, or a history of heart attack or stroke, as it may increase cardiovascular risks. It is contraindicated in uncontrolled high blood pressure.
  • Liver and Kidney Impairment: Use with caution in patients with mild to moderate liver or kidney problems. It is not recommended for severe liver or kidney disease.
  • Gastrointestinal Issues: Avoid if you have stomach ulcers, gastrointestinal bleeding, or inflammatory bowel disease.
  • Other Conditions: Use with caution if you are dehydrated, have diabetes, or high cholesterol levels.
  • Children and Elderly: Not recommended for use in children below 16 years of age. Caution is advised for older patients (above 70 years of age) due to increased susceptibility to side effects and potential liver/kidney issues.
  • Driving and Machinery: May cause dizziness or fatigue; avoid driving or operating heavy machinery until you know how it affects you.
  • Alcohol: Consumption of alcohol with Nucoxia 120 Tablet is unsafe.
  • Drug Interactions: Caution is needed when using with anticoagulants and high doses of aspirin or other NSAIDs, as this may increase the risk of stomach ulcers and bleeding.

• Storage

  • Store in a cool and dry place, away from direct sunlight.
  • Keep out of sight and reach of children.
  • Typically stored at temperatures between 10ºC to 25ºC or below 30ºC.

NUCOXIA 120 TABLET, manufactured by Zydus Cadila, contains Etoricoxib as its active ingredient. Etoricoxib is a non-steroidal anti-inflammatory drug (NSAID) that belongs to the class of selective COX-2 inhibitors, used to relieve pain and inflammation.

What is Nucoxia 120 Tablet used for?

Nucoxia 120 Tablet is primarily used to reduce pain, swelling, and inflammation associated with various conditions. These include osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, and acute gouty arthritis. It is also prescribed for the short-term treatment of moderate pain following dental surgery.

How does Nucoxia 120 Tablet work?

Nucoxia 120 Tablet contains Etoricoxib, which works by selectively inhibiting the cyclooxygenase-2 (COX-2) enzyme. This enzyme is responsible for producing prostaglandins, chemical messengers that cause pain, swelling, and inflammation in the body. By blocking COX-2, Nucoxia 120 Tablet reduces the production of these prostaglandins, thereby alleviating pain and inflammation. Its selective action on COX-2 helps in minimizing the risk of gastrointestinal side effects compared to traditional non-selective NSAIDs.

What is the usual dosage for Nucoxia 120 Tablet?

The dosage of Nucoxia 120 Tablet depends on the condition being treated and should always be as prescribed by your doctor. For acute gouty arthritis, the typical dose is 120 mg once daily, limited to a maximum of 8 days. For postoperative dental surgery pain, it may be 90 mg once daily for a maximum of 3 days. For other conditions like osteoarthritis, rheumatoid arthritis, or ankylosing spondylitis, your doctor might prescribe lower strengths (e.g., 30 mg, 60 mg, or 90 mg) once daily, adjusting as necessary. The tablet should be swallowed whole with a glass of water, with or without food, and should not be crushed or chewed. It is important to use the lowest effective dose for the shortest duration necessary. This medicine is not recommended for children under 16 years of age.

What are the possible side effects of Nucoxia 120 Tablet?

Common side effects can include stomach pain, indigestion, nausea, vomiting, diarrhea, constipation, flatulence, heartburn, headache, dizziness, and swelling of the legs or feet (edema). Other reported side effects include dry socket, palpitations, increased blood pressure, shortness of breath, flu-like symptoms, and mouth ulcers. More serious, but less frequent, side effects can include an increased risk of heart attack, stroke, kidney or liver issues, gastrointestinal bleeding or ulcers, and severe allergic reactions.

Is Nucoxia 120 Tablet safe during pregnancy or breastfeeding?

Nucoxia 120 Tablet is generally not recommended and is contraindicated during pregnancy, as it may show toxic effects on the fetus, potentially delaying labor and leading to malformations. For breastfeeding mothers, it is also advised to use with caution or avoid, and only if prescribed by a doctor, as it is unknown if the medicine passes into human milk and animal studies suggest it could affect prostaglandin production in infants. Always consult your doctor for advice if you are pregnant, planning to conceive, or breastfeeding.

Can Nucoxia 120 Tablet be taken with other medications?

Nucoxia 120 Tablet can interact with various medications. It may increase the risk of bleeding when taken with blood thinners like warfarin, requiring close monitoring of INR. Its effectiveness might be reduced when taken with diuretics and certain blood pressure medications (ACE inhibitors, ARBs), and could potentially worsen kidney function. Combining it with other NSAIDs or high-dose aspirin can increase the risk of stomach ulcers. It may also interact with medications like rifampicin, methotrexate, cyclosporine, tacrolimus, lithium, digoxin, oral salbutamol, and minoxidil. It is crucial to inform your doctor about all medicines, supplements, or herbal products you are currently taking to avoid possible interactions. However, it can generally be taken with paracetamol.

What precautions should be taken while using Nucoxia 120 Tablet?

Before taking Nucoxia 120 Tablet, inform your doctor if you have a history of stomach ulcers or bleeding, severe liver or kidney disease, heart problems (e.g., heart failure, high blood pressure, history of heart attack or stroke), diabetes, high cholesterol, or conditions causing fluid retention or dehydration. Regular monitoring of blood pressure, especially during the first two weeks of treatment, is recommended. As Nucoxia 120 Tablet can cause dizziness or sleepiness, avoid driving or operating heavy machinery until you know how it affects you. Alcohol consumption is generally discouraged as it may increase the risk of heart problems, drowsiness, and stomach issues.

What happens if a dose of Nucoxia 120 Tablet is missed?

If you miss a dose of Nucoxia 120 Tablet, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the forgotten one.

How should Nucoxia 120 Tablet be stored?

Nucoxia 120 Tablet should be stored in a cool and dry place, away from direct sunlight, heat, and air. Keep it out of the sight and reach of children.