Progynova 1 Mg Tablet (28 Tab)

PROGYNOVA 1 MG TABLET (28 TAB) by BAYER ZYDUS PHARMA PVT. LTD.

Progynova 1 mg Tablet is a form of hormone replacement therapy (HRT) manufactured by Bayer Zydus Pharma Pvt. Ltd..

• Name

  • Brand Name: Progynova 1 mg Tablet
  • Common Name: Estradiol Valerate

• Composition

  • Active Ingredient: Each tablet contains 1 mg of Estradiol Valerate, a synthetic form of the female hormone estradiol.
  • Inactive Ingredients: Lactose, maize starch, povidone, purified talc, magnesium stearate, sucrose, macrogol 6000, calcium carbonate, glycerol, glycol montanate, titanium dioxide, and iron oxide yellow.

• Uses Progynova 1 mg Tablet is primarily used for hormone replacement therapy to address estrogen deficiency. It is prescribed for:

  • Alleviating symptoms associated with menopause, such as hot flashes, vaginal dryness, itching, night sweats, and mood swings.
  • Treating hypoestrogenism (estrogen deficiency).
  • Preventing and managing postmenopausal osteoporosis (thinning of bones).
  • In some fertility protocols, it aids in preparing the uterine lining for implantation during assisted reproductive technologies like IVF.
  • Management of menstrual disorders such as heavy menstrual bleeding and painful menstruation.

• Dosage and Administration

  • Typically, one Progynova 1 mg tablet is taken daily.
  • Tablets should be swallowed whole with some liquid, with or without food.
  • It is recommended to take the tablet at the same time each day to maintain consistency.
  • Treatment is usually continuous, meaning the next pack follows immediately without a break.
  • If a dose is missed, it can be taken within 12 to 24 hours. If more than 12 hours late, the missed tablet should not be taken, and the regular schedule continued. Do not take a double dose.

• Side Effects Common side effects include headaches, bloating, nausea, breast pain/tenderness, weight gain, hair loss, and irregular vaginal bleeding or spotting. Serious side effects, though rare, can include breast lumps, severe headaches, dizziness, chest pain, shortness of breath, leg pain (indicating blood clots), and vision disturbances.

• Precautions

  • Inform your doctor about any history of breast cancer, vaginal bleeding, blood clots, liver or kidney disease, or heart conditions.
  • Progynova is not recommended during pregnancy or breastfeeding.
  • Avoid consuming grapefruit juice and St. John's wort, as they can interfere with the medication.
  • Smoking should be avoided as it increases the risk of blood clots, stroke, and heart attack.
  • Regular medical check-ups are advised while on this medication.

• Storage

  • Store in a cool and dry place away from direct sunlight, moisture, and heat.
  • Keep out of sight and reach of children.
  • Progynova 1 mg Tablets should be stored below 30°C.

What is Progynova 1 mg Tablet used for?

Progynova 1 mg Tablet is primarily used as a hormone replacement therapy (HRT) to alleviate symptoms associated with menopause. These symptoms can include hot flashes, night sweats, vaginal dryness, burning, itching, and mood swings. It is also prescribed to address estrogen deficiency (hypoestrogenism) and to help prevent postmenopausal osteoporosis (thinning of bones) in women who are at high risk of fractures and have limited other treatment options. Additionally, it may be used in fertility treatments to prepare the uterine lining and in managing certain menstrual disorders.

How does Progynova 1 mg Tablet work?

Progynova 1 mg Tablet contains estradiol valerate, which is a prodrug of 17β-estradiol, a natural human estrogen. It works by replacing the estrogen that the body no longer produces sufficiently, particularly during and after menopause. By binding to estrogen receptors in various tissues, it mimics the effects of natural estrogen, thereby relieving menopausal symptoms and supporting bone density.

What is the usual dosage for Progynova 1 mg Tablet?

The usual dosage is one Progynova 1 mg tablet taken daily. It should be swallowed whole with some liquid, with or without food. It's important to take the tablet at the same time each day. Treatment is typically continuous, meaning the next pack follows immediately without a break. Your doctor will determine the appropriate dose and duration of treatment based on your individual needs and medical condition, aiming for the lowest effective dose for the shortest possible duration.

What are the possible side effects of Progynova 1 mg Tablet?

Common side effects may include headaches, breast pain or tenderness, irregular vaginal bleeding or spotting, bloating, nausea, vomiting, abdominal cramps, hair loss, and weight changes. More serious, though rare, side effects can include breast lumps, severe headaches, chest pain, shortness of breath, leg pain (which could indicate a blood clot), and vision abnormalities. If you experience any severe or persistent side effects, or warning signs, you should seek immediate medical attention.

Is Progynova 1 mg Tablet safe during pregnancy or breastfeeding?

No, Progynova 1 mg Tablet is not recommended for use during pregnancy as it may affect the developing baby. If you become pregnant while taking this medicine, you should stop immediately and inform your doctor. It is also not recommended for breastfeeding mothers, as the active ingredient can pass into breast milk and potentially affect the baby.

Can Progynova 1 mg Tablet be taken with other medications?

Progynova 1 mg Tablet can interact with certain medications. These include medicines for epilepsy (e.g., phenytoin, primidone, carbamazepine), tuberculosis (e.g., rifampicin), HIV (e.g., ritonavir, nevirapine), some antibiotics (e.g., clarithromycin, erythromycin), and some medicines for high blood pressure or irregular heartbeat. Herbal remedies containing St. John's Wort should also be avoided. Always inform your doctor or pharmacist about all other medicines, supplements, or herbal products you are taking to prevent potential interactions.

What precautions should be taken when using Progynova 1 mg Tablet?

Before starting Progynova, your doctor should conduct a thorough medical and gynecological examination, including breast checks, and periodically thereafter. Inform your doctor if you have a history of blood clots, breast cancer, liver disease, undiagnosed vaginal bleeding, heart or kidney disease, high blood pressure, diabetes, asthma, or a family history of certain cancers. Smoking should be avoided as it significantly increases the risk of blood clots, stroke, and heart attack. Grapefruit juice can also interfere with the medication and should be avoided.

What happens if a dose of Progynova 1 mg Tablet is missed?

If you miss a dose, take it as soon as you remember, provided it is within 12 to 24 hours of the usual time. If more than 12-24 hours have passed or it's almost time for your next dose, skip the missed tablet and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one, as this may lead to irregular bleeding.

How should Progynova 1 mg Tablet be stored?

Progynova 1 mg tablets should be stored below 30°C in a cool, dry place, away from moisture, heat, and direct sunlight. Keep the tablets in their original pack until it's time to take them, and ensure they are out of the reach of children.