Daparyl 5 Tablet

DAPARYL 5 TABLET

DAPARYL 5 TABLET, manufactured by Intas Pharmaceuticals Ltd., is a medication used to manage various conditions, primarily focusing on metabolic and cardiovascular health.

Composition

DAPARYL 5 TABLET contains Dapagliflozin 5mg as its active ingredient. It belongs to a class of medicines known as sodium-glucose co-transporter 2 (SGLT2) inhibitors.

Uses

DAPARYL 5 TABLET is prescribed for the following medical conditions:

• Type 2 Diabetes Mellitus: It helps to lower high blood glucose (sugar) levels, either alone or in combination with other antidiabetic medicines, when diet and exercise alone are insufficient. It works by removing excess sugar from the body through urine, reducing the risk of complications such as kidney damage, eye damage, nerve problems, and loss of limbs.
• Heart Failure: It is used in adults to treat heart failure, where the heart does not pump blood efficiently, helping to protect the heart, reduce symptoms, and lower the chances of hospitalization.
• Chronic Kidney Disease: It is also used in adults with reduced kidney function to protect the kidneys from further damage and may help some individuals live longer.

Dosage and Administration

DAPARYL 5 TABLET should be taken in the dose and duration advised by your doctor. It is typically taken once daily, with or without food, and swallowed whole with a glass of water. It is recommended to take it at the same time each day to maintain consistent blood sugar levels. Do not chew, crush, or break the tablet. Do not stop taking it without consulting your doctor, as this may lead to increased blood sugar levels and serious complications.

Side Effects

Common side effects associated with DAPARYL 5 TABLET include:

• Genital fungal infections (e.g., vaginal yeast infections, thrush), which can cause itching, irritation, and unusual discharge. Practicing good hygiene can help prevent these infections.
• Urinary tract infections (UTIs).
• Nausea.
• Polyuria (increased frequency of urination).
• Dehydration and increased thirst; it is important to drink plenty of fluids.
• Nasopharyngitis (inflammation of the throat and nasal passages).
• Back pain.
• Dizziness.
• Skin rash.
• Low blood sugar (hypoglycemia), especially when taken with other antidiabetic medicines or alcohol, or if a meal is delayed or missed. Symptoms include cold sweats, cool pale skin, tremors, and anxiety. It is advisable to carry sugary food or fruit juice.

Serious side effects that require immediate medical attention include signs of an allergic reaction (skin rash, itching, swelling of the face, tongue, or throat, difficulty breathing or swallowing) and diabetic ketoacidosis (nausea or vomiting, stomach pain, excessive thirst, fast and deep breathing, confusion, unusual sleepiness, a sweet smell to breath, or rapid weight loss).

Precautions

• Allergies: Do not take DAPARYL 5 TABLET if you are allergic to dapagliflozin or any of its components.
• Pregnancy and Breastfeeding: It is not recommended during pregnancy (especially in the second and third trimesters) and breastfeeding. Consult your doctor if you are pregnant, planning pregnancy, or breastfeeding.
• Kidney and Liver Problems: Use with caution in patients with kidney disease, and it is not recommended for those with severe kidney impairment, end-stage kidney disease, or on dialysis. While generally safe for liver disease patients if prescribed, caution is advised.
• Dehydration: Inform your doctor if you have severe low blood pressure or are severely dehydrated due to excessive vomiting or diarrhea, as the medicine may cause further fluid loss.
• Alcohol Consumption: It is unsafe to consume alcohol with DAPARYL 5 TABLET as it may affect blood glucose levels and increase the risk of certain side effects.
• Other Medications: Inform your doctor about all other medicines, including diuretics (water pills), insulin, and other antidiabetic medications, as interactions can occur leading to very low blood sugar levels or increased risk of dehydration.
• Children and Elderly: The use of DAPARYL 5 TABLET is generally not recommended for children below 18 years. Elderly patients (above 65 years) should use it with caution and under medical supervision as they may be more susceptible to side effects.
• Driving: Your ability to drive may be affected if your blood sugar is too low or too high.

Storage

Store DAPARYL 5 TABLET below 30°C. Keep it in a cool and dry place, away from sunlight and moisture. Keep out of sight and reach of children.

DAPARYL 5 TABLET contains Dapagliflozin, an active ingredient that belongs to a class of medications called sodium-glucose co-transporter 2 (SGLT2) inhibitors. It is primarily used to manage blood sugar levels in adults with type 2 diabetes.

Here are some frequently asked questions about DAPARYL 5 TABLET:

What is DAPARYL 5 TABLET used for?

DAPARYL 5 TABLET is primarily used to manage type 2 diabetes mellitus in adults, often in conjunction with diet and exercise, to improve blood sugar control. Additionally, it is prescribed for adults to reduce the risk of cardiovascular death and hospitalization for heart failure, and to lower the risk of worsening kidney disease, end-stage kidney disease, cardiovascular death, and hospitalization for heart failure in adults with chronic kidney disease.

How does DAPARYL 5 TABLET work?

DAPARYL 5 TABLET, with its active ingredient Dapagliflozin, works by inhibiting the sodium-glucose co-transporter 2 (SGLT2) protein in the kidneys. This action prevents the kidneys from reabsorbing excess glucose back into the bloodstream, leading to increased glucose excretion in the urine and thus lowering blood sugar levels. This mechanism also contributes to its benefits in heart failure and chronic kidney disease by influencing fluid balance and reducing the workload on the heart and kidneys.

What is the usual dosage of DAPARYL 5 TABLET?

For improving glycemic control in type 2 diabetes, the usual starting dose is 5 mg once daily, which may be increased to 10 mg once daily if needed. For other indications such as heart failure and chronic kidney disease, the recommended dose for adults is typically 10 mg once daily. It should be taken once a day, with or without food, preferably at the same time each day.

What are the possible side effects of DAPARYL 5 TABLET?

Common side effects can include urinary tract infections, genital yeast infections (in both men and women), increased urination, stuffy or runny nose, sore throat, back pain, and dizziness. More serious, though rare, side effects can include dehydration, ketoacidosis (a serious condition with high levels of ketones in the blood), and acute kidney injury. If you experience severe nausea, vomiting, stomach pain, confusion, unusual drowsiness, difficulty breathing, or symptoms of a serious allergic reaction (hives, swelling of the face/lips/tongue/throat), seek immediate medical attention.

Is DAPARYL 5 TABLET safe during pregnancy or breastfeeding?

DAPARYL 5 TABLET (dapagliflozin) is generally not recommended during the second and third trimesters of pregnancy due to potential risks of kidney problems in the developing fetus. If you are pregnant or planning to become pregnant, discuss alternative diabetes management options with your doctor. Similarly, dapagliflozin is not usually recommended while breastfeeding, as it is unknown how much of the medication passes into breast milk and there's a potential for serious adverse reactions or kidney development issues in a breastfed infant.

Can DAPARYL 5 TABLET be taken with other medications?

DAPARYL 5 TABLET can be taken with other medications, but it's important to inform your doctor about all prescription, over-the-counter, and herbal supplements you are taking. Taking dapagliflozin with insulin or sulfonylureas may increase the risk of low blood sugar (hypoglycemia), and your doctor may need to adjust the dose of these medications. Combining it with diuretics ("water pills") can increase the risk of dehydration and low blood pressure.

What precautions should be taken while taking DAPARYL 5 TABLET?

Before starting DAPARYL 5 TABLET, your doctor should assess your fluid status and kidney function. You should stay well-hydrated to reduce the risk of dehydration and low blood pressure. Monitor for symptoms of urinary tract infections and genital yeast infections, and report them to your doctor promptly. It is crucial to be aware of the signs of ketoacidosis (nausea, vomiting, stomach pain, confusion, trouble breathing) and seek immediate medical attention if they occur, even if blood sugar levels are not very high. If you are scheduled for surgery, your doctor may advise you to stop taking dapagliflozin at least 3 days beforehand. DAPARYL 5 TABLET is not for people with type 1 diabetes or for treating diabetic ketoacidosis.

What happens if a dose of DAPARYL 5 TABLET is missed?

If you miss a dose of DAPARYL 5 TABLET, take it as soon as you remember. However, if it is almost time for your next scheduled dose (e.g., less than 12 hours until the next dose), skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.

How should DAPARYL 5 TABLET be stored?

DAPARYL 5 TABLET should be stored at room temperature, typically between 68°F and 77°F (20°C and 25°C). Keep the medication protected from light and moisture, and out of the reach of children.