Terbitotal 500

TERBITOTAL 500 by MACLEODS PHARMACEUTICALS PVT LTD

Name:

• Brand Name: TERBITOTAL 500
• Common Name: Terbinafine (as Terbinafine Hydrochloride)

Composition:

• Active Ingredient: Terbinafine (500mg)

Uses: TERBITOTAL 500 is an antifungal medication primarily used to treat a wide range of fungal infections. It is prescribed for:

• Fungal infections of the toenails and fingernails (onychomycosis)
• Scalp ringworm (tinea capitis), especially in children
• Ringworm of the body (tinea corporis)
• Jock itch (tinea cruris)
• Athlete's foot (tinea pedis)

Dosage and Administration: TERBITOTAL 500 tablets are typically taken once daily, with or without food. The duration of treatment varies based on the type and severity of the infection:

• Fingernail infections: Usually 6 weeks.
• Toenail infections: Usually 12 weeks.
• Skin infections (tinea corporis/cruris/pedis): Typically 2 to 6 weeks. It is important to complete the full course of treatment as prescribed by a healthcare professional, even if symptoms improve.

Side Effects:

• Common Side Effects: Headache, diarrhea, indigestion, nausea, vomiting, stomach pain, rash, itching, and a change or loss of taste or smell.
• Serious Side Effects: Liver problems (yellowing of skin/eyes, dark urine, pale stools, right upper abdominal pain), severe skin reactions (blistering, peeling rash), blood disorders, pancreatitis, lupus-like syndrome, inflammation of blood vessels, and severe allergic reactions. Contact a doctor immediately if any serious side effects occur.

Precautions:

• Liver Function: Not recommended for patients with chronic or active liver disease. Liver function tests may be monitored before and during treatment.
• Kidney Impairment: Use with caution; dose adjustment may be necessary.
• Pregnancy and Breastfeeding: Generally not recommended during breastfeeding as terbinafine can pass into breast milk. Consult a doctor if pregnant or planning to conceive.
• Drug Interactions: May interact with certain medications metabolized by CYP2D6 (e.g., beta-blockers, some antidepressants) and other drugs like cimetidine, rifampin, and warfarin. Avoid caffeine.
• Sun Sensitivity: May increase skin sensitivity to sunlight; protective clothing and sunscreen are advised.
• Other Conditions: Use with caution in patients with a weakened immune system or lupus.

Storage: Store TERBITOTAL 500 tablets in a cool and dry place, below 25°C or 30°C, away from direct sunlight. Keep out of the reach of children.

TERBITOTAL 500, manufactured by Macleods Pharmaceuticals Pvt Ltd, contains the active ingredient Terbinafine (500mg). It is an antifungal medication primarily used to treat various fungal infections of the skin and nails.

What is TERBITOTAL 500 used for?

TERBITOTAL 500 is used to treat fungal infections, including those affecting the fingernails and toenails (onychomycosis), as well as fungal skin infections such as ringworm (tinea corporis), athlete's foot (tinea pedis), and jock itch (tinea cruris). It can also be used for fungal infections of the scalp (tinea capitis).

How does TERBITOTAL 500 work?

Terbinafine, the active ingredient in TERBITOTAL 500, is an allylamine antifungal. It works by inhibiting a specific enzyme called squalene epoxidase within the fungal cell membrane. This action prevents the production of ergosterol, a vital component of the fungal cell wall, and leads to an accumulation of squalene. This disruption weakens the fungal cell membrane, causing the fungal cells to die and stopping the infection from spreading.

What is the usual dosage for TERBITOTAL 500?

TERBITOTAL 500 contains 500mg of Terbinafine. The exact dosage and duration of treatment will be determined by your doctor based on the type and severity of your fungal infection. Oral terbinafine tablets are typically taken once a day. For nail infections, treatment can range from 6 weeks for fingernails to 12 weeks for toenails. For skin infections like ringworm, athlete's foot, or jock itch, a 250 mg daily dose for 2 to 4 weeks is common for the active ingredient, though your doctor will specify the correct use of the 500mg tablet for your condition.

What are the possible side effects of TERBITOTAL 500?

Common side effects can include headache, diarrhea, indigestion, nausea, vomiting, stomach pain, loss of appetite, changes in taste or smell (which can sometimes be prolonged or permanent), skin rash, itching, and muscle or joint pain. More serious but rare side effects can include liver problems (yellowing of skin or eyes, dark urine, pale stools, severe stomach pain), severe skin reactions, allergic reactions (swelling of the face or throat, difficulty breathing), and blood disorders. You should contact your doctor immediately if you experience any serious side effects.

Is TERBITOTAL 500 safe during pregnancy or breastfeeding?

Pregnancy: TERBITOTAL 500 (Terbinafine tablets) is generally not recommended during pregnancy due to limited conclusive studies in pregnant women. Treatment for fungal nail infections can often be postponed until after pregnancy. If you are pregnant or planning to become pregnant, discuss the risks and benefits with your doctor.

Breastfeeding: Terbinafine passes into breast milk, and manufacturers typically advise against breastfeeding while taking oral terbinafine. While some limited research suggests low levels in milk, it's recommended to consult your doctor, who may suggest alternative antifungals or advise on monitoring the infant for potential side effects.

Can TERBITOTAL 500 be taken with other medications?

Terbinafine can interact with several medications by affecting certain liver enzymes (CYP2D6). It may increase the levels or effects of drugs such as tricyclic antidepressants, beta-blockers, selective serotonin reuptake inhibitors (SSRIs), antiarrhythmics (like amiodarone), caffeine, cyclosporine, cimetidine, and warfarin. Conversely, it might decrease the effect of medications like tamoxifen and codeine. Always inform your doctor and pharmacist about all prescription and non-prescription medications, vitamins, nutritional supplements, and herbal products you are taking. Medications like pimozide and thioridazine should generally not be taken with terbinafine.

What precautions should be taken while on TERBITOTAL 500?

It's important to inform your doctor if you have a history of liver disease, kidney disease, lupus, or a weakened immune system. Your doctor may recommend regular blood tests, especially liver function tests, to monitor for any adverse effects. You should limit or avoid exposure to direct sunlight and tanning beds, as terbinafine can increase your skin's sensitivity to the sun; wear protective clothing and use sunscreen when outdoors. Report any changes in your sense of taste or smell, mood changes (such as depression), or symptoms of liver problems to your doctor immediately. It is crucial to complete the entire prescribed course of treatment, even if symptoms improve, to ensure the infection is fully cleared and to prevent recurrence.

What happens if a dose of TERBITOTAL 500 is missed?

If you miss a dose of TERBITOTAL 500, take it as soon as you remember. However, if it is almost time for your next scheduled dose (typically less than 4 hours away), skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to compensate for a missed one.

How should TERBITOTAL 500 be stored?

TERBITOTAL 500 tablets should be stored in a closed container at room temperature, away from excessive heat, moisture, and direct light. It's generally recommended to store them below 25°C or 30°C and to keep them out of the reach of children. Do not use any medicine that is outdated.