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Istamet G Ir 50/1000/2
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Istamet G Ir 50/1000/2

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Source ID: 262671

₹154.22

₹115.97

(Inclusive of all taxes)
Delivery Details
Hadapsar

Batch

GTG1147C

PKG

10 TABLET

Expiry

2027-03-31

MRP

₹154.22

Stock

2

Discount

24.8%

Description

ISTAMET G IR 50/1000/2 Tablet

ISTAMET G IR 50/1000/2 Tablet is a combination medication used in the management of Type 2 Diabetes Mellitus. It is manufactured by SUN PHARMA LABORATORIES LTD.

  • Name

    • Brand Name: ISTAMET G IR 50/1000/2 Tablet
    • Common Name: Sitagliptin Phosphate, Metformin, Glimepiride (combination)

  • Composition Each tablet contains a fixed-dose combination of:

    • Sitagliptin Phosphate: 50 mg
    • Metformin: 1000 mg
    • Glimepiride: 2 mg

  • Uses ISTAMET G IR 50/1000/2 is prescribed for the following in adults with Type 2 Diabetes Mellitus:

    • Management of high blood sugar levels when diet, exercise, and single-agent treatments are not sufficient.
    • Control of blood sugar levels.
    • Improvement of glycemic control.
    • Support for insulin sensitivity.
    • Reducing the risk of serious diabetes-associated complications such as kidney damage, eye damage, nerve problems, and heart diseases.

  • Dosage and Administration

    • Take ISTAMET G IR 50/1000/2 as prescribed by your healthcare provider.
    • It is typically taken by mouth with meals to reduce the risk of gastrointestinal side effects and prevent low blood sugar episodes.
    • Swallow the tablet whole with a glass of water; do not crush, break, or chew it.
    • The dosage and duration are determined by the doctor based on your blood sugar levels and response to treatment. Do not change the dose without consulting your doctor.

  • Side Effects

    • Common Side Effects: Nausea, vomiting, diarrhea, abdominal pain, headache, hypoglycemia (low blood sugar), nasopharyngitis, upper respiratory tract infection, flatulence, loss of appetite, and taste disturbance.
    • Serious Side Effects: Lactic acidosis (a rare but serious condition), severe allergic reactions (e.g., skin rash, hives, difficulty breathing), inflammation of the liver (jaundice), and severe low blood sugar levels, including loss of consciousness and seizures. Seek immediate medical attention if these worsen or occur.

  • Precautions

    • Pregnancy and Breastfeeding: This medicine should be avoided during pregnancy, especially during the second and third trimesters, and is not recommended during breastfeeding due to potential harm to the baby.
    • Alcohol: Avoid or limit alcohol consumption as it may increase the risk of hypoglycemia and lactic acidosis.
    • Kidney and Liver Conditions: Use with caution in patients with kidney or liver problems. Dose adjustments may be necessary, and it is contraindicated in severe kidney or liver disease.
    • Elderly Patients: Special caution is recommended in the elderly due to an increased risk of hypoglycemia; regular monitoring is necessary.
    • Children: Safety and efficacy have not been established in children under 18 years of age.
    • Driving and Operating Machinery: May cause dizziness or drowsiness, especially if hypoglycemia occurs. Avoid driving or operating heavy machinery if these symptoms are experienced.
    • Drug Interactions: Inform your healthcare provider about all medications you are currently taking, including herbal supplements, to avoid potential interactions. Interactions can occur with carbonic anhydrase inhibitors, kidney transport inhibitors, and beta-blockers.

  • Storage

    • Store ISTAMET G IR 50/1000/2 at room temperature, ideally below 25°C or 30°C.
    • Protect from moisture and direct light.
    • Keep out of the reach and sight of children and pets.

Frequently Asked Questions

What is ISTAMET G IR 50/1000/2 used for?

ISTAMET G IR 50/1000/2 is an antidiabetic medicine used to manage high blood sugar levels in adults with Type 2 diabetes mellitus. It is typically prescribed when diet, exercise, and single-agent treatments are not sufficient to control blood sugar.

How does ISTAMET G IR 50/1000/2 work?

This medicine is a combination of three active ingredients: Glimepiride, Metformin, and Sitagliptin. Glimepiride stimulates the pancreas to produce more insulin. Metformin works by reducing glucose production by the liver and delaying sugar absorption from the intestines, while also increasing the body's sensitivity to insulin. Sitagliptin increases the levels of natural substances (incretins) that help the pancreas release more insulin when blood sugar is high and signal the liver to reduce sugar production.

What is the usual dosage for ISTAMET G IR 50/1000/2?

ISTAMET G IR 50/1000/2 should be taken exactly as prescribed by your doctor. It is usually recommended to take it once daily in the morning, preferably with food, to minimize stomach upset. Do not crush, break, or chew the tablet; swallow it whole with a glass of water. Your doctor will determine the appropriate dose based on your blood sugar levels and response to treatment.

What are the possible side effects of ISTAMET G IR 50/1000/2?

Common side effects may include nausea, vomiting, abdominal pain, headache, diarrhea, and frequent urination. A serious potential side effect is hypoglycemia (low blood sugar), especially if taken with other antidiabetic medicines, alcohol, or if meals are missed. Other serious but rare side effects include lactic acidosis (a build-up of lactic acid in the body) and severe allergic reactions. If you experience persistent or worsening side effects, or symptoms of lactic acidosis (e.g., muscle pain, weakness, dizziness, difficulty breathing), seek immediate medical attention.

Is ISTAMET G IR 50/1000/2 safe during pregnancy or breastfeeding?

ISTAMET G IR 50/1000/2 is generally not recommended and may be unsafe to use during pregnancy, especially during the second and third trimesters, as it may harm the unborn baby. It is also generally not recommended during breastfeeding as components of the medicine may pass into breast milk and potentially harm the infant. Always inform your doctor if you are pregnant, planning a pregnancy, or breastfeeding before taking this medication.

Can ISTAMET G IR 50/1000/2 be taken with other medications?

ISTAMET G IR 50/1000/2 can interact with various other medications. It is crucial to inform your doctor about all medicines, supplements, and herbal products you are currently taking to avoid potential drug interactions. Some medications, such as carbonic anhydrase inhibitors, kidney transport inhibitors, beta-blockers, antibiotics, diuretics, and corticosteroids, may interact with ISTAMET G IR 50/1000/2.

What precautions should be taken while using ISTAMET G IR 50/1000/2?

Inform your doctor about any existing medical conditions, especially severe kidney or liver disease, heart problems, or a history of pancreatitis. Avoid alcohol consumption while on this medication, as it increases the risk of hypoglycemia and lactic acidosis. Close monitoring of blood sugar levels is essential. Caution is advised if you drive or operate machinery, as this medicine can cause dizziness or drowsiness due to low blood sugar.

What happens if a dose of ISTAMET G IR 50/1000/2 is missed?

If you miss a dose of ISTAMET G IR 50/1000/2, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to compensate for the missed one, as this can lead to a rapid drop in blood sugar levels.

How should ISTAMET G IR 50/1000/2 be stored?

Store ISTAMET G IR 50/1000/2 in a cool, dry place at a temperature below 25°C or 30°C, away from direct sunlight and moisture. Keep it in its original packaging and out of the sight and reach of children and pets. Do not use the medicine after its expiry date.